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师资队伍
王少华
职务/职称:院长/药物化学研究所所长/三级教授/博导
研 究 所:药物化学研究所
联系电话:0931-8915683
电子邮件:wangshh@lzu.edu.cn
办 公 室:杏林楼609
  • 个人简介
  • 研究成果
  • 研究项目
  • 【基本情况】

    王少华,教授,博士研究生导师,全球十大网赌正规官网院长,国家高层次人才青年项目入选者。2001年、2006年在澳门国际娱乐十大网站化学与化工学院分别获得学士及博士学位;2006-2011年在美国梅奥医学中心做博士后研究;2011年至今在全球十大网赌正规官网工作。主要研究方向为药物活性分子的设计与合成。合作发表高水平学术期刊论文80余篇,参与撰写中外文专著 5部;获美国专利授权 1 项,中国发明专利授权 9 项;主持国家重点研发项目课题、国家自然科学基金项目、企业合作项目等课题30余项; 负责国家一流课程1门、甘肃省一流课程1门,参与建设甘肃省精品课程1门。入选2020年江苏省双创人才,2021年甘肃省领军人才和2022年兰州市城关区“科技精英”;并受邀担任《化学通报》《Pharmaceutical Science Advances》副主编,《有机化学》《中华全科医学》《化学学报》青年编委,甘肃省药学学会副理事长、国家药监局中药材及饮片质量控制重点实验室副主任、甘肃省化学原料药中间体行业技术中心主任。

    【研究方向】

    药物活性的小分子的设计与合成、药物活性天然产物的高效合成及功能机制研究

    【主讲课程】

    本科生《仪器分析》、《分析化学》、《分析化学实验》,研究生《专业英语》

    【获奖情况】

    2006年 甘肃省高等学校科技成果一等奖

    2014年 甘肃省精品课程(第二完成人);

    2015年 教育部自然科学一等奖(第四完成人)

    2015年 澳门国际娱乐十大网站医学院本科实践教学优秀指导教师

    2016年 国家自然科学二等奖(第四完成人)

    2016年 澳门国际娱乐十大网站优秀共产党员

    2016年 澳门国际娱乐十大网站本科毕业论文优秀指导教师

    2016年 澳门国际娱乐十大网站创新创业行动计划“优秀指导教师”

    2017年 甘肃省普通高等学校青年教师成才奖

    2017年 澳门国际娱乐十大网站青年五四奖章

    2017年 澳门国际娱乐十大网站本科毕业论文优秀指导教师

    2019年 澳门国际娱乐十大网站隆基教学新秀奖

    2019年 澳门国际娱乐十大网站本科毕业论文优秀指导教师

    2019年 澳门国际娱乐十大网站“三走进”工作先进个人

    2020年 江苏省双创人才

    2020年 澳门国际娱乐十大网站萃英学者

    2020年 甘肃省一流课程

    2021年 澳门国际娱乐十大网站优秀共产党员

    2021年 甘肃省领军人才

    2023年 国家一流课程负责人

    2022年 兰州市城关区“科技精英”

    2023年 甘肃省研究生教育优秀导师

    2023年 澳门国际娱乐十大网站隆基教学骨干奖

    2023年 澳门国际娱乐十大网站教学成果二等奖

    2023年 甘肃省智库课题研究成果奖

    2023年 澳门国际娱乐十大网站“学科建设先进个人”


  • 1.Liu, W.-T.; Xu, Z.-L.; Mou, X.-Q.; Zhang, B.-H.; Bao, W.; Wang, S.-H.; Lee, D.; Lei, L.-S.; Zhang, K., The synthesis of cycloalka[b]furans via an Au(i)-catalyzed tandem reaction of 3-yne-1,2-diols. Organic & Biomolecular Chemistry 2017, 15 (30), 6333-6337.

    2.Zhang, B.-H.; Lei, L.-S.; Liu, S.-Z.; Mou, X.-Q.; Liu, W.-T.; Wang, S.-H.; Wang, J.; Bao, W.; Zhang, K., Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles. Chemical Communications 2017, 53 (61), 8545-8548.

    3.Zhang, X.-M.; Tu, Y.-Q.; Zhang, F.-M.; Chen, Z.-H.; Wang, S.-H., Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis. Chemical Society Reviews 2017, 46 (8), 2272-2305.

    4.Shao, H.; Bao, W.; Jing, Z.-R.; Wang, Y.-P.; Zhang, F.-M.; Wang, S.-H.; Tu, Y.-Q., Construction of the [6,5,7,5] Tetracyclic Core of Calyciphylline A Type Alkaloids via a Tandem Semipinacol Rearrangement/Nicholas Reaction. Organic Letters 2017, 19 (17), 4648-4651.

    5.Liu, L.; Cheng, H.-L.; Ma, W.-Q.; Hou, S.-H.; Tu, Y.-Q.; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H., Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C-H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization. Chemical Communications 2018, 54 (2), 196-199.

    6.Bao, W.; Wang, J.-Q.; Xu, X.-T.; Zhang, B.-H.; Liu, W.-T.; Lei, L.-S.; Liang, H.; Zhang, K.; Wang, S.-H., Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines. Chemical Communications 2018, 54 (59), 8194-8197.

    7.Liu, L.; Lei, L.-S.; Zhan, Z.-S.; Liu, S.-Z.; Wang, Y.-X.; Tu, Y.-Q.; Zhang, F.-M.; Zhang, X.-M.; Ma, A.-J.; Wang, S.-H., A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] skeleton. Chemical Communications 2019, 55 (26), 3789-3792[1]

    8.Lei, L.-S.; Xue, C.-G.; Xu, X.-T.; Jin, D.-P.; Wang, S.-H.; Bao, W.; Liang, H.; Zhang, K.; Asiri, A. M., The synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles. Organic & Biomolecular Chemistry 2019, 17 (15), 3723-3726.

    9.Xu, X.; Chen, J.; Lin, Z.; Li, D.; Zhang, K.; Sheng, Z.; Wang, S.; Zhu, S.; Abdullah M. A. Synthesis and Anti-inflammatory Effects of Oxaprozin-Paeonol Ester[J]. Chinese Journal of Organic Chemistry, 2019, 39(10): 2958-2964.

    10.Zhang, Y.; Zheng, T.-L.; Cheng, F.; Dai, K.-L.; Zhang, K.; Ma, A.-J.; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H.; Tu, Y.-Q. Facile access to diverse all-carbon quaternary center containing spirobicycles by exploring a tandem Castro–Stephens coupling/acyloxy shift/cyclization/semipinacol rearrangement sequence. Chemical Science 2020, 11, 3878-3884.

    11. Bao, W.; Gao, Z.-P.; Jin, D.-P.; Xue, C.-G.; Liang, H.; Lei, L.-S.; Xu, X.-T.; Zhang, K.; Wang, S.-H., Direct synthesis of 2-substituted benzonitriles via alkylcyanation of arynes with N,N-disubstituted aminomalononitriles. Chemical Communications 2020, 56 (55), 7641-7644.

    12.Lei, L.-S.; Wang, B.-W.; Jin, D.-P.; Gao, Z.-P.; Huan, L.; Wang, S.-H.; Xu, X.-T.; Zhang, K.; Zhang, X.-Y., Al(OTf)3-Catalyzed Tandem Coupling Reaction between N,N-Disubstituted Aminomalonitriles and Substituted Arenes: a Synthesis of 1-Cyano-bisindolylmethane Analogues. Advanced Synthesis & Catalysis 2020, 362 (14), 2870-2875.

    13.Xu, X.-T.; Deng, X.-Y.; Chen, J.; Liang, Q.-M.; Zhang, K.; Li, D.-L.; Wu, P.-P.; Zheng, X.; Zhou, R.-P.; Jiang, Z.-Y.; Ma, A.-J.; Chen, W.-H.; Wang, S.-H., Synthesis and biological evaluation of coumarin derivatives as α-glucosidase inhibitors. European Journal of Medicinal Chemistry 2020, 189, 112013.

    14.Zheng, T.-L.; Zhang, Y.; Gou, A. L.; Cheng, F.; Liu, S.-Z.; Yu, L.; Cui, M.-Y.; Xu, X.-T.; Zhang, K.; Wang, S.-H., Au(I)-Catalyzed Cyclization/Semipinacol Rearrangement Reaction of Allenes to Construct Quaternary Carbon-Containing Scaffolds. Organic Letters 2020, 22 (18), 7073-7077.

    15.Liang, H.; Gou, A.; Gao, Z.; Lei, L.; Wang, B.; Yu, L.; Xu, X.; Wang, S., A New Strategy for the Synthesis of Tertiary Amides via a Copper-Catalyzed Decyanation Reaction of N,N-Disubstituted 2-Aminomalononitriles. Acta Chim. Sinica 2020, 78, 1064.

    16.Wang Shaohua, Z. B., Chen Jie, Zheng Yingying, Feng Na, Ma Aijun, Xu Xuetao, Abdullah M. Asiri, Recent Progress in Synthesis of Polysubstituted Pyrazoles. Chinese Journal of Organic Chemistry 2020, 40 (1), 15-27.

    17.Zheng, T.-L.; Liu, S.-Z.; Huo, C.-Y.; Li, J.; Wang, B.-W.; Jin, D.-P.; Cheng, F.; Chen, X.-M., Zhang, X.-M.; Xu, X.-T.; Wang, S.-H., Au-Catalyzed 1,3-Acyloxy Migration/Cyclization Cascade: A Direct Strategy toward the Synthesis of Functionalized Abietane-Type Diterpenes. CCS Chemistry 2020, 2, 2795.

    18.Xu, X.-T.; Chen Jie, Ke Junjie, Zhang Kun, Wu Panpan, Wang Shaohua, Recent Advances on Pyrrole Synthesis through Different Annulation Modes. Chinese Journal of Organic Chemistry 2021, 41, 206-228.

    19.Zheng, P.-F.; Xiong, Z.; Liao, C.-y.; Zhang, X.; Feng, M.; Wu, X.-Z.; Lin, J.; Lei, L.-S.; Zhang, Y.-C.; Wang, S.-H.; Xu, X.-T., In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 2021, 36 (1), 1938-1951.

    20.Zhang, X.-M.; Li, B.-S.; Wang, S.-H.; Zhang, K.; Zhang, F.-M.; Tu, Y.-Q., Recent development and applications of semipinacol rearrangement reactions. Chemical Science 2021, 12 (27), 9262-9274.

    21.Liu, S.-Z.; Li, J.; Xue, C.-G.; Xu, X.-T.; Lei, L.-S.; Huo, C.-Y.; Wang, Z.; Wang, S.-H., Copper-promoted cyanation of aryl iodides with N,N-dimethyl aminomalononitrile. Tetrahedron Letters 2021, 65, 152749.

    22.Jin, D.-P.; Gao, Z.-P.; Liu, L.; Cao, S.-Q.; Xu, X.-T.; Hou, X.-W.; Zheng, T.-L.; Jiang, L.-M.; Zhu, D.-Y.; Wang, S.-H., Total Synthesis of (±)-Furanether A. Organic Letters 2021, 23 (22), 8843-8846.

    23.Cheng, F.; Duan, D.-S.; Zhang, Y.; Zheng, T.-L.; Zhang, X.-Y.; Wang, S.-H.; Xu, X.-T.; Zhu, D.-Y., Total synthesis of (±)-erythrodiene and (±)-spirojatamol. Tetrahedron Letters 2021, 85, 153291.

    24.Liu, Sizhan; Cui, Mingyue; Wang, Bowen; Hu, Chunmei; Zheng, Yingying; Li, Jing; Xu, Xuetao; Wang, Zhen; Wang, Shaohua; Triethyl Amine-Promoted Cyclization Reaction between Cyclopropenone and alpha-Halogenated Hydroxamate for the Synthesis of Polysubstituted 6H-1,3-Oxazin-6-one, Chinese Journal of Organic Chemistry, 2021, 41(4), 1622-1630.

    25.Cheng, F.; Duan, D.-S.; Jiang, L.-M.; Li, B.-S.; Wang, J.-X.; Zhou, Y.-J.; Jiao, H.-Y.; Wu, T.; Zhu, D.-Y.; Wang, S.-H., Copper-Catalyzed Asymmetric Ring-Opening Reaction of Cyclic Diaryliodonium Salts with Imides. Organic Letters 2022, 24 (6), 1394-1399.

    26.Li, J.; Jiang, L.-M.; Cheng, F.; Zhou, Y.-J.; Duan, D.-S.; Zhu, D.-Y.; Zhang, K.; Xiong, Z.; Wang, S.-H., Total synthesis of sinopyrine B. Tetrahedron Letters 2022, 106, 154072.

    27.Huo, Chen-Yu; Zheng, Tian-Lu; Dai, Wei-Hao; Zhang, Zi-Hao; Wang, Jin-Da; Zhu, Dao-Yong;*    Wang, Shao-Hua;* Zhang, Xiao-Ming; Xu, Xue-Tao; InI3-catalyzed polyene cyclization of allenes and its application in the total synthesis of seven abietane-type diterpenoids. Chemical Science 2022, 13, 13893-13897.

    28.Jin, D.-P.; Cao, S.-Q.; Cheng, F.; Xue, Z.-S.; Li, R.-Z.; Pu, Y.-L.; Zhu, D.-Y.; Bao, W.; Xu, X.-T.; Wang, S.-H., A Gold(I)-Catalyzed Cyclization/Semipinacol Rearrangement Cascade of 1,6-Enynes to Access Spiro[4.5]decanes and 7-Azaspiro[4.5]decanes. Advanced Synthesis & Catalysis 2023, 365 (3), 312-317.

    29.Zhang, B.-H.; Bao, W.; Cheng, F.; Yu, K.-Y.; Wang, J.-X.; Zhang, Z.-H.; Dong, L.-J.; Xue, Z.-S.; Zhu, D.-Y.; Xu, X.-T.; Wang, S.-H., Rh(I)-Catalyzed [5 + 2]/[2 + 2] Cycloaddition Cascade to Access a Cyclobutane-Fused [4–5–6–7] Tetracyclic Framework. Organic Letters 2023, 25 (14), 2405-2409.

    30.Chen, X.; Yao, W.; Zheng, H.; Wang, H.; Zhou, P.-P.; Zhu, D.-Y.; Wang, S.-H., Enantiocontrolled Total Synthesis of (−)-Retigeranic Acid A. Journal of the American Chemical Society 2023, 145 (25), 13549-13555.

    31.Dong, L.-J.; Wang,  Q.; Zhang, J.-F.; Li, Z.; Zhu, D.-Y.; Zhang, X.-M.;* Tu, Y.-Q.; Wang, S.-H., Catalytic Asymmetric Synthesis of Vicinal Quaternary Stereocenters Enabled by Alkylation of α,α-Disubstituted Aldehydes with 3-Bromooxindoles. Organic Letters, 2024, 26, 3086-3090

    32.Li, M.; Li, H.; Min, X.; Sun,J.; Liang, B.; Xu, L.; Li, J.;* Wang, S.-H.;* Xu, X.,* Identification of 1,3,4-Thiadiazolyl-Containing Thiazolidine-2,4-dione Derivatives as Novel PTP1B Inhibitors with Antidiabetic Activity. Journal of Medicinal Chemistry, 2024, 67,  8406-8419.

    33.Duan, D.; Ma, Y.; Liu, Y.; Cheng, F.; Zhu, D.-Y.;* Wang, S.-H.,* Visible Light-Induced Decarbon-Carboxylation of Activated Alkenes by Carbon Dioxide. Chinese Journal of Organic Chemistry, 2024, 44(5), 1675-1685.

    34.Feng, M.; Liang, B.; Sun, J.; Min, X.; Wang, S.-H.,* Lu, Y.;* Xu, X.,* Synthesis, anti-α-glucosidase activity, inhibition interaction, and anti-diabetic activity of novel cryptolepine derivatives. Journal of Molecular Structure, 2024, 1310, 138311.

    35.Teng, C.-C.; Guo, Y.; Cao, K.;* Yang, H.-B.; Jiang, Q.-J.; Zhu, D.-Y.;* Wang, S.-H.,* Palladium catalyzed selective arylation of B(4)-H of o-carboranes with potassium aryltrifluoroborate. Journal of Organometallic Chemistry 2024, 1008, 123051.

    36.Zhang, Y.-T.; Hou, X.-W.; Cheng, F.; Huo, C.-Y.; Li, J.; Xu, X.; Zhu, D.-Y.;* Wang, S.-H.,* Collective syntheses of five abietane-type diterpenoids using a polyene cyclization strategy. Tetrahedron Letters 2024, 140, 155023.

    37.Wang, J.-X.; Xiang, K.; Hou, K.-L.; Ma, Y.; Xu, X.; Zhu, D.-Y.;* Wang, S.-H.,* Transition metal-free access to 3-indolemalononitriles via a tandem decarboxylative propargylation/aromatization cascade. Tetrahedron Letters 2024, 142, 155098.

    38.Wu, S.; Tang, J.; Zhou, Y.; Xu, X.;* Zhang, H.;* Wang, S.-H.,* α-Glucosidase Inhibition Research of Derivatives Based on 2β-Acetoxyferruginol Scaffold Excluding Acetic Acid Group. Chinese Journal of Organic Chemistry, 2024, 44, 613-621.

    39.Hu, C.; Liang, B.; Sun, J.; Li, J.; Xiong, Z.; Wang, S.-H.;* Xu, X.;* Synthesis and biological evaluation of indole derivatives containing thiazolidine-2,4-dione as α-glucosidase inhibitors with antidiabetic activity. European Journal of Medicinal Chemistry 2024, 264, 115957.

    40.Zhou, Y.; Qu, H.; Qiao, X.; Wang, S.-H.;* 2β-Acetoxyferruginol derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation. Bioorganic Chemistry, 2024, 152, 107770.


  • 【1】国家重点研发计划项目子课题,2023YFA1506404,负责人;

    【2】国家自然科学基金面上项目,21772071,负责人;

    【3】国家自然科学基金面上项目,21472077,负责人;

    【4】国家自然科学基金青年基金项目,21202073,负责人;

    【5】甘肃省科技重大专项,23ZDFA003,负责人;

    【6】甘肃省自然科学基金重点项目,23JRRA1028,负责人;

    【7】甘肃省自然科学基金科技专员项目,23CXGA0043,负责人;

    【8】甘肃省自然科学基金项目,20JR10RA608,负责人;

    【9】国家“重大新药创制”科技重大专项子课题,2012ZX09201-101 -003,参与。


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